BDBM274886 2-Fluoro-N-(6-(2-(4-fluorophenyl)-7-pivaloyl- 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3- yl)imidazo[1,2-b]pyridazin-2- yl)isonicotinamide::US9556179, Compound 464
SMILES: CC(C)(C)C(=O)N1CCn2c(C1)nc(c2-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
InChI Key: InChIKey=FMJJAOHMMMACIR-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Casein kinase I isoform delta (Homo sapiens (Human)) | BDBM274886 (2-Fluoro-N-(6-(2-(4-fluorophenyl)-7-pivaloyl- 5,6,...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company US Patent | Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst... | US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Casein kinase I isoform epsilon (Homo sapiens (Human)) | BDBM274886 (2-Fluoro-N-(6-(2-(4-fluorophenyl)-7-pivaloyl- 5,6,...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company US Patent | Assay Description The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst... | US Patent US9556179 (2017) BindingDB Entry DOI: 10.7270/Q2G73GR5 | |||||||||||
More data for this Ligand-Target Pair |