BDBM27490 2-amino-3-{4-[(3-methoxypropyl)sulfamoyl]phenyl}-5-phenylbenzamide::Amino-substituted diarylbenzamide, 8w

SMILES: COCCCNS(=O)(=O)c1ccc(cc1)-c1cc(cc(C(N)=O)c1N)-c1ccccc1

InChI Key: InChIKey=HAFBRQDBRQDCSQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 27490   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit alpha (Homo sapiens (Human))	BDBM27490 (2-amino-3-{4-[(3-methoxypropyl)sulfamoyl]phenyl}-5...) Show SMILES COCCCNS(=O)(=O)c1ccc(cc1)-c1cc(cc(C(N)=O)c1N)-c1ccccc1 Show InChI InChI=1S/C23H25N3O4S/c1-30-13-5-12-26-31(28,29)19-10-8-17(9-11-19)20-14-18(16-6-3-2-4-7-16)15-21(22(20)24)23(25)27/h2-4,6-11,14-15,26H,5,12-13,24H2,1H3,(H2,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	794	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...				Bioorg Med Chem Lett 17: 3972-7 (2007) Article DOI: 10.1016/j.bmcl.2007.04.088 BindingDB Entry DOI: 10.7270/Q2QZ289W
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM27490 (2-amino-3-{4-[(3-methoxypropyl)sulfamoyl]phenyl}-5...) Show SMILES COCCCNS(=O)(=O)c1ccc(cc1)-c1cc(cc(C(N)=O)c1N)-c1ccccc1 Show InChI InChI=1S/C23H25N3O4S/c1-30-13-5-12-26-31(28,29)19-10-8-17(9-11-19)20-14-18(16-6-3-2-4-7-16)15-21(22(20)24)23(25)27/h2-4,6-11,14-15,26H,5,12-13,24H2,1H3,(H2,25,27)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...				Bioorg Med Chem Lett 17: 3972-7 (2007) Article DOI: 10.1016/j.bmcl.2007.04.088 BindingDB Entry DOI: 10.7270/Q2QZ289W
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM27490 (2-amino-3-{4-[(3-methoxypropyl)sulfamoyl]phenyl}-5...) Show SMILES COCCCNS(=O)(=O)c1ccc(cc1)-c1cc(cc(C(N)=O)c1N)-c1ccccc1 Show InChI InChI=1S/C23H25N3O4S/c1-30-13-5-12-26-31(28,29)19-10-8-17(9-11-19)20-14-18(16-6-3-2-4-7-16)15-21(22(20)24)23(25)27/h2-4,6-11,14-15,26H,5,12-13,24H2,1H3,(H2,25,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...				Bioorg Med Chem Lett 17: 3972-7 (2007) Article DOI: 10.1016/j.bmcl.2007.04.088 BindingDB Entry DOI: 10.7270/Q2QZ289W
					More data for this Ligand-Target Pair