BDBM27538 4-[(3-{[4-(morpholin-4-ylcarbonyl)-1,4-diazepan-1-yl]carbonyl}phenyl)methyl]-1,2-dihydrophthalazin-1-one::Homopiperazine analogue, 19

SMILES: O=C(N1CCOCC1)N1CCCN(CC1)C(=O)c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1

InChI Key: InChIKey=ONYUSAYXJHUYGG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27538   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM27538 (4-[(3-{[4-(morpholin-4-ylcarbonyl)-1,4-diazepan-1-...) Show SMILES O=C(N1CCOCC1)N1CCCN(CC1)C(=O)c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1 Show InChI InChI=1S/C26H29N5O4/c32-24-22-8-2-1-7-21(22)23(27-28-24)18-19-5-3-6-20(17-19)25(33)29-9-4-10-30(12-11-29)26(34)31-13-15-35-16-14-31/h1-3,5-8,17H,4,9-16,18H2,(H,28,32)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	22
KuDOS Pharmaceuticals Ltd.					Assay Description A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...				J Med Chem 51: 6581-91 (2008) Article DOI: 10.1021/jm8001263 BindingDB Entry DOI: 10.7270/Q2BP014T
					More data for this Ligand-Target Pair