null
SMILES: Nc1ncnc2n(CC3CCN(CC3)C(=O)C=C)c(=O)n(-c3ccc(Oc4ccccc4)cc3)c12
InChI Key: InChIKey=OODFMLQWPHKOIJ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK/Lck (Homo sapiens (Human)) | BDBM275473 (US9879013, 8(14)) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ONO PHARMACEUTICAL CO., LTD. US Patent | Assay Description The Btk enzyme inhibitory activity was measured, based on the protocol provided by the manufacturer, using Btk (Invitrogen Corporation) and the ZR... | US Patent US9879013 (2018) BindingDB Entry DOI: 10.7270/Q2X63PZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK/Lyn (Homo sapiens (Human)) | BDBM275473 (US9879013, 8(14)) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.77E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
ONO PHARMACEUTICAL CO., LTD. US Patent | Assay Description The Btk enzyme inhibitory activity was measured, based on the protocol provided by the manufacturer, using Btk (Invitrogen Corporation) and the ZR... | US Patent US9879013 (2018) BindingDB Entry DOI: 10.7270/Q2X63PZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK/Fyn (Homo sapiens (Human)) | BDBM275473 (US9879013, 8(14)) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
ONO PHARMACEUTICAL CO., LTD. US Patent | Assay Description The Btk enzyme inhibitory activity was measured, based on the protocol provided by the manufacturer, using Btk (Invitrogen Corporation) and the ZR... | US Patent US9879013 (2018) BindingDB Entry DOI: 10.7270/Q2X63PZ1 | |||||||||||
More data for this Ligand-Target Pair |