null
SMILES: COc1ccc(CC(=O)NC(=N)N[C@H](Cc2ccccc2)C(=O)NCc2cccc(c2)-c2ccn(C)n2)cc1OC
InChI Key: InChIKey=OEFDGSFEUMNFMH-AREMUKBSSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cathepsin D (Homo sapiens (Human)) | BDBM275707 (US9884814, Compound 321) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 240 | n/a | n/a | n/a | n/a | 5.5 | 25 |
MERCK PATENT GMBH US Patent | Assay Description In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores... | US Patent US9884814 (2018) BindingDB Entry DOI: 10.7270/Q25Q4Z3V | |||||||||||
More data for this Ligand-Target Pair |