BDBM275807 5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)oxy)-2-fluoro- N-((1-methyl-1H- imidazol-4-yl) sulfonyl)benzamide::US10071957, Example 24

SMILES: CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cn(C)cn2)cc1Cl

InChI Key: InChIKey=VDQZTORBBDPDKC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275807   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275807 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cn(C)cn2)cc1Cl Show InChI InChI=1S/C20H19Cl2FN4O5S/c1-11(2)9-31-20-15(22)4-12(7-24-20)32-17-6-16(23)13(5-14(17)21)19(28)26-33(29,30)18-8-27(3)10-25-18/h4-8,10-11H,9H2,1-3H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	578	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275807 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cn(C)cn2)cc1Cl Show InChI InChI=1S/C20H19Cl2FN4O5S/c1-11(2)9-31-20-15(22)4-12(7-24-20)32-17-6-16(23)13(5-14(17)21)19(28)26-33(29,30)18-8-27(3)10-25-18/h4-8,10-11H,9H2,1-3H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair