BDBM275849 5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)oxy)-2-fluoro- N-(morpholino- sulfonyl)benzamide::US10071957, Example 68

SMILES: CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCOCC2)cc1Cl

InChI Key: InChIKey=XAJPNMMCDMIZFH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275849   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275849 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCOCC2)cc1Cl Show InChI InChI=1S/C20H22Cl2FN3O6S/c1-12(2)11-31-20-16(22)7-13(10-24-20)32-18-9-17(23)14(8-15(18)21)19(27)25-33(28,29)26-3-5-30-6-4-26/h7-10,12H,3-6,11H2,1-2H3,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	77	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
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