BDBM275851 5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-(2-fluoro- 5-(trifluoromethoxy) phenoxy)benzamide::US10071957, Example 70

SMILES: CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cc(OC(F)(F)F)ccc2F)cc1F

InChI Key: InChIKey=DMOWZHLXAOOOBV-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275851   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275851 (5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-(2...) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cc(OC(F)(F)F)ccc2F)cc1F Show InChI InChI=1S/C16H12ClF5N2O5S/c1-24(2)30(26,27)23-15(25)9-6-10(17)13(7-12(9)19)28-14-5-8(3-4-11(14)18)29-16(20,21)22/h3-7H,1-2H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	340	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
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