BDBM27630 N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]phenyl}-3-(trifluoromethyl)benzamide::alpha-methylbenzylamino pyrazine deriv., 12

SMILES: C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1

InChI Key: InChIKey=HPFAGQREBCZBHM-LBPRGKRZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27630   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27630 (N-{3-[(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl]ph...) Show SMILES C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 |r| Show InChI InChI=1S/C20H16ClF3N4O/c1-12(26-18-11-25-10-17(21)28-18)13-4-3-7-16(9-13)27-19(29)14-5-2-6-15(8-14)20(22,23)24/h2-12H,1H3,(H,26,28)(H,27,29)/t12-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	37
Cytopia Research Pty Ltd					Assay Description Kinase assays were performed in 384 well Optiplates (Packard) using an Alphascreen Protein Tyrosine Kinase kit. Inhibitors were added to the mixtures...				Bioorg Med Chem Lett 19: 1206-9 (2009) Article DOI: 10.1016/j.bmcl.2008.12.073 BindingDB Entry DOI: 10.7270/Q2PZ5742
					More data for this Ligand-Target Pair