BDBM277034 US10072001, Example 226::US10259811, Example 226

SMILES: N#Cc1cc(ccc1OC1CCOCC1)-c1ncnc2[nH]c(cc12)-c1ccc(OCCN2CCCC2)cc1

InChI Key: InChIKey=ZULNHRNAEOVNJO-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 277034   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM277034 (US10072001, Example 226 | US10259811, Example 226) Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ncnc2[nH]c(cc12)-c1ccc(OCCN2CCCC2)cc1 Show InChI InChI=1S/C30H31N5O3/c31-19-23-17-22(5-8-28(23)38-25-9-14-36-15-10-25)29-26-18-27(34-30(26)33-20-32-29)21-3-6-24(7-4-21)37-16-13-35-11-1-2-12-35/h3-8,17-18,20,25H,1-2,9-16H2,(H,32,33,34)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.0	n/a
Gilead Sciences, Inc. US Patent					Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...				US Patent US10072001 (2018) BindingDB Entry DOI: 10.7270/Q27H1MMV
					More data for this Ligand-Target Pair
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM277034 (US10072001, Example 226 | US10259811, Example 226) Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ncnc2[nH]c(cc12)-c1ccc(OCCN2CCCC2)cc1 Show InChI InChI=1S/C30H31N5O3/c31-19-23-17-22(5-8-28(23)38-25-9-14-36-15-10-25)29-26-18-27(34-30(26)33-20-32-29)21-3-6-24(7-4-21)37-16-13-35-11-1-2-12-35/h3-8,17-18,20,25H,1-2,9-16H2,(H,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.24	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo					Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...				Bioorg Med Chem 16: 4272-85 (2008) BindingDB Entry DOI: 10.7270/Q2ZG6VKC
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM277034 (US10072001, Example 226 | US10259811, Example 226) Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ncnc2[nH]c(cc12)-c1ccc(OCCN2CCCC2)cc1 Show InChI InChI=1S/C30H31N5O3/c31-19-23-17-22(5-8-28(23)38-25-9-14-36-15-10-25)29-26-18-27(34-30(26)33-20-32-29)21-3-6-24(7-4-21)37-16-13-35-11-1-2-12-35/h3-8,17-18,20,25H,1-2,9-16H2,(H,32,33,34)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo					Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...				Bioorg Med Chem 16: 4272-85 (2008) BindingDB Entry DOI: 10.7270/Q2ZG6VKC
					More data for this Ligand-Target Pair
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM277034 (US10072001, Example 226 | US10259811, Example 226) Show SMILES N#Cc1cc(ccc1OC1CCOCC1)-c1ncnc2[nH]c(cc12)-c1ccc(OCCN2CCCC2)cc1 Show InChI InChI=1S/C30H31N5O3/c31-19-23-17-22(5-8-28(23)38-25-9-14-36-15-10-25)29-26-18-27(34-30(26)33-20-32-29)21-3-6-24(7-4-21)37-16-13-35-11-1-2-12-35/h3-8,17-18,20,25H,1-2,9-16H2,(H,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.24	n/a	n/a	n/a	n/a	7.0	n/a
Gilead Sciences, Inc. US Patent					Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...				US Patent US10072001 (2018) BindingDB Entry DOI: 10.7270/Q27H1MMV
					More data for this Ligand-Target Pair