null

SMILES: CC(C)(O)c1ccc(cc1)-c1nc2c(ncnc2[nH]1)-c1ccc(OC2CCOCC2)c(c1)C#N

InChI Key: InChIKey=BDDBUOVVYOJPSW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 277036   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM277036 (US10072001, Example 228 | US10259811, Example 228) Show SMILES CC(C)(O)c1ccc(cc1)-c1nc2c(ncnc2[nH]1)-c1ccc(OC2CCOCC2)c(c1)C#N Show InChI InChI=1S/C26H25N5O3/c1-26(2,32)19-6-3-16(4-7-19)24-30-23-22(28-15-29-25(23)31-24)17-5-8-21(18(13-17)14-27)34-20-9-11-33-12-10-20/h3-8,13,15,20,32H,9-12H2,1-2H3,(H,28,29,30,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.5	n/a	n/a	n/a	n/a	7.0	n/a
Gilead Sciences, Inc. US Patent					Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...				US Patent US10072001 (2018) BindingDB Entry DOI: 10.7270/Q27H1MMV
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM277036 (US10072001, Example 228 | US10259811, Example 228) Show SMILES CC(C)(O)c1ccc(cc1)-c1nc2c(ncnc2[nH]1)-c1ccc(OC2CCOCC2)c(c1)C#N Show InChI InChI=1S/C26H25N5O3/c1-26(2,32)19-6-3-16(4-7-19)24-30-23-22(28-15-29-25(23)31-24)17-5-8-21(18(13-17)14-27)34-20-9-11-33-12-10-20/h3-8,13,15,20,32H,9-12H2,1-2H3,(H,28,29,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.62	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo					Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...				Bioorg Med Chem 16: 4272-85 (2008) BindingDB Entry DOI: 10.7270/Q2ZG6VKC
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM277036 (US10072001, Example 228 | US10259811, Example 228) Show SMILES CC(C)(O)c1ccc(cc1)-c1nc2c(ncnc2[nH]1)-c1ccc(OC2CCOCC2)c(c1)C#N Show InChI InChI=1S/C26H25N5O3/c1-26(2,32)19-6-3-16(4-7-19)24-30-23-22(28-15-29-25(23)31-24)17-5-8-21(18(13-17)14-27)34-20-9-11-33-12-10-20/h3-8,13,15,20,32H,9-12H2,1-2H3,(H,28,29,30,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo					Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...				Bioorg Med Chem 16: 4272-85 (2008) BindingDB Entry DOI: 10.7270/Q2ZG6VKC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM277036 (US10072001, Example 228 | US10259811, Example 228) Show SMILES CC(C)(O)c1ccc(cc1)-c1nc2c(ncnc2[nH]1)-c1ccc(OC2CCOCC2)c(c1)C#N Show InChI InChI=1S/C26H25N5O3/c1-26(2,32)19-6-3-16(4-7-19)24-30-23-22(28-15-29-25(23)31-24)17-5-8-21(18(13-17)14-27)34-20-9-11-33-12-10-20/h3-8,13,15,20,32H,9-12H2,1-2H3,(H,28,29,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.62	n/a	n/a	n/a	n/a	7.0	n/a
Gilead Sciences, Inc. US Patent					Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...				US Patent US10072001 (2018) BindingDB Entry DOI: 10.7270/Q27H1MMV
					More data for this Ligand-Target Pair