BDBM277123 7-{[2-(difluoromethoxy)pyridin-4- yl]methyl}-4-(3-methylisothiazol-5-yl)- 5,6,7,8-tetrahydro-1,7-naphthyridine-2- carboxamide::US10072003, Example 2-16
SMILES: Cc1cc(sn1)-c1cc(nc2CN(Cc3ccnc(OC(F)F)c3)CCc12)C(N)=O
InChI Key: InChIKey=BVHAYYRVDLDUJM-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM277123 (7-{[2-(difluoromethoxy)pyridin-4- yl]methyl}-4-(3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.67E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA US Patent | Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon... | US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK | |||||||||||
More data for this Ligand-Target Pair |