BDBM277128 7-[(1-methyl-1H-1,2,3-triazol-5-yl)methyl]- 4-(2,4,6-trifluorophenyl)-5,6,7,8-tetrahydro- 1,7-naphthyridine-2-carboxamide::US10072003, Example 2-21

SMILES: Cn1nncc1CN1CCc2c(C1)nc(cc2-c1c(F)cc(F)cc1F)C(N)=O

InChI Key: InChIKey=SETNCMGJXATHCN-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 277128   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277128 (7-[(1-methyl-1H-1,2,3-triazol-5-yl)methyl]- 4-(2,4...) Show SMILES Cn1nncc1CN1CCc2c(C1)nc(cc2-c1c(F)cc(F)cc1F)C(N)=O |(-2.82,.77,;-4.15,1.54,;-5.61,1.06,;-6.52,2.31,;-5.61,3.56,;-4.15,3.08,;-2.82,3.85,;-1.48,3.08,;-1.48,1.54,;-.15,.77,;1.18,1.54,;1.18,3.08,;-.15,3.85,;2.52,3.85,;3.85,3.08,;3.85,1.54,;2.52,.77,;2.52,-.77,;1.18,-1.54,;-.15,-.77,;1.18,-3.08,;2.52,-3.85,;2.52,-5.39,;3.85,-3.08,;3.85,-1.54,;5.19,-.77,;5.19,3.85,;6.52,3.08,;5.19,5.39,)| Show InChI InChI=1S/C19H17F3N6O/c1-27-11(7-24-26-27)8-28-3-2-12-13(6-16(19(23)29)25-17(12)9-28)18-14(21)4-10(20)5-15(18)22/h4-7H,2-3,8-9H2,1H3,(H2,23,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
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