BDBM277159 US10072003, Example 7-1::US10072003, Example 7-2

SMILES: CC(N1CCc2c(C1)nc(cc2-c1ccc(F)cc1F)C(N)=O)c1cnnn1C

InChI Key: InChIKey=RGCDODFOMCDOAW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277159   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277159 (US10072003, Example 7-1 | US10072003, Example 7-2) Show SMILES CC(N1CCc2c(C1)nc(cc2-c1ccc(F)cc1F)C(N)=O)c1cnnn1C Show InChI InChI=1S/C20H20F2N6O/c1-11(19-9-24-26-27(19)2)28-6-5-14-15(13-4-3-12(21)7-16(13)22)8-17(20(23)29)25-18(14)10-28/h3-4,7-9,11H,5-6,10H2,1-2H3,(H2,23,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM277159 (US10072003, Example 7-1 | US10072003, Example 7-2) Show SMILES CC(N1CCc2c(C1)nc(cc2-c1ccc(F)cc1F)C(N)=O)c1cnnn1C Show InChI InChI=1S/C20H20F2N6O/c1-11(19-9-24-26-27(19)2)28-6-5-14-15(13-4-3-12(21)7-16(13)22)8-17(20(23)29)25-18(14)10-28/h3-4,7-9,11H,5-6,10H2,1-2H3,(H2,23,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...				US Patent US10072003 (2018) BindingDB Entry DOI: 10.7270/Q23R0VXK
					More data for this Ligand-Target Pair