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SMILES: NC(=O)c1cc(c2CCN(Cc3ccnc(n3)C(F)(F)F)Cc2n1)-c1c(F)cccc1Cl

InChI Key: InChIKey=BLNMWYOJCJHNQV-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 277187   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM277187
PNG
(4-(2-chloro-6-fluorophenyl)-7-{[2- (trifluoromethy...)
Show SMILES NC(=O)c1cc(c2CCN(Cc3ccnc(n3)C(F)(F)F)Cc2n1)-c1c(F)cccc1Cl |(-8,-2.31,;-6.67,-3.08,;-6.67,-4.62,;-5.33,-2.31,;-5.33,-.77,;-4,,;-2.67,-.77,;-1.33,,;,-.77,;,-2.31,;1.33,-3.08,;2.67,-2.31,;2.67,-.77,;4,,;5.33,-.77,;5.33,-2.31,;4,-3.08,;6.67,-3.08,;8,-2.31,;6.67,-4.62,;8,-3.85,;-1.33,-3.08,;-2.67,-2.31,;-4,-3.08,;-4,1.54,;-5.33,2.31,;-6.67,1.54,;-5.33,3.85,;-4,4.62,;-2.67,3.85,;-2.67,2.31,;-1.33,1.54,)|
Show InChI InChI=1S/C21H16ClF4N5O/c22-14-2-1-3-15(23)18(14)13-8-16(19(27)32)30-17-10-31(7-5-12(13)17)9-11-4-6-28-20(29-11)21(24,25)26/h1-4,6,8H,5,7,9-10H2,(H2,27,32)
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 4.52E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...

US Patent US10072003 (2018)


BindingDB Entry DOI: 10.7270/Q23R0VXK
More data for this
Ligand-Target Pair