BDBM278483 (2S)-2-(dimethylamino)-2-(o-tolyl)-N-[5-[[(3R)-::US10040789, Example 17

SMILES: CN(C)[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1C

InChI Key: InChIKey=QKVJMGFCCLINQD-QAPCUYQASA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278483   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM278483 ((2S)-2-(dimethylamino)-2-(o-tolyl)-N-[5-[[(3R)- | ...) Show SMILES CN(C)[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1C |r| Show InChI InChI=1S/C21H26N8OS/c1-14-7-4-5-8-16(14)18(28(2)3)19(30)24-21-27-26-20(31-21)23-15-10-12-29(13-15)17-9-6-11-22-25-17/h4-9,11,15,18H,10,12-13H2,1-3H3,(H,23,26)(H,24,27,30)/t15-,18+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	187	n/a	n/a	n/a	n/a	7.8	25
AstraZeneca AB; Cancer Research Technology Limited US Patent					Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...				US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9
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