BDBM278594 (2E)-3-(1-{[3-(2,6-Dichloro-4- methylphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 56
SMILES: Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(C)cc2Cl)c2cccc(\C=C\C(O)=O)c12
InChI Key: InChIKey=YJTOZPRYQQAIKI-CMDGGOBGSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IDH1 R132C (Homo sapiens (Human)) | BDBM278594 ((2E)-3-(1-{[3-(2,6-Dichloro-4- methylphenyl)-5-(2-...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 107 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Daiichi Sankyo Company, Limited; National Cancer Center US Patent | Assay Description The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov... | US Patent US10040791 (2018) BindingDB Entry DOI: 10.7270/Q2JS9SF8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) (Homo sapiens (Human)) | BDBM278594 ((2E)-3-(1-{[3-(2,6-Dichloro-4- methylphenyl)-5-(2-...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Daiichi Sankyo Company, Limited; National Cancer Center US Patent | Assay Description The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov... | US Patent US10040791 (2018) BindingDB Entry DOI: 10.7270/Q2JS9SF8 | |||||||||||
More data for this Ligand-Target Pair |