BDBM278874 2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(4-bromothiophen- 3-yl)thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 53
SMILES: OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3cscc3Br)c2n1
InChI Key: InChIKey=GVCILKLDPWJHIT-ZVWHLABXSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human)) | BDBM278874 (2-{[(1R,2S)-2-amino- cyclohexyl]amino}- N-(4-bromo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp... | US Patent US10040802 (2018) BindingDB Entry DOI: 10.7270/Q298891C | |||||||||||
More data for this Ligand-Target Pair |