Found 9 hits for monomerid = 27889 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Macrophage colony stimulating factor receptor
(Homo sapiens (Human)) | BDBM27889
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1 Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical
| Assay Description FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ... |
J Med Chem 52: 1081-99 (2009)
Article DOI: 10.1021/jm801406h BindingDB Entry DOI: 10.7270/Q21834T7 |
More data for this Ligand-Target Pair | |
Macrophage colony stimulating factor receptor
(Homo sapiens (Human)) | BDBM27889
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1 Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of ATP-induced CSF1R autophosphorylation |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM27889
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1 Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of FLT3 |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM27889
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1 Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of KIT |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM27889
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1 Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of Src |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM27889
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1 Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of TrkA |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Macrophage colony stimulating factor receptor
(Homo sapiens (Human)) | BDBM27889
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1 Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of CSF1R |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM27889
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1 Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >300 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of Axl |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM27889
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[4-(4-methylpiper...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(cc(C(N)=O)c3=O)-c2ccc3CCCc3c2)cc1 Show InChI InChI=1S/C28H29N7O2/c1-33-11-13-34(14-12-33)21-9-6-20(7-10-21)31-28-30-16-23-25(36)24(26(29)37)17-35(27(23)32-28)22-8-5-18-3-2-4-19(18)15-22/h5-10,15-17H,2-4,11-14H2,1H3,(H2,29,37)(H,30,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta |
Bioorg Med Chem Lett 18: 2355-61 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.070 BindingDB Entry DOI: 10.7270/Q26W9BX3 |
More data for this Ligand-Target Pair | |