BDBM279094 5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 125::US10512632, Example 125::US10766893, Example S125::US10806718, Example 125

SMILES: CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC

InChI Key: InChIKey=SYWOKLNWWYOPHL-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 279094   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5 (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279094 (5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...) Show SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C25H30N6O2/c1-6-16(3)31-24-22(28-14-18-11-19(32-5)15-26-13-18)12-21(29-23(24)17(4)30-31)20-9-8-10-27-25(20)33-7-2/h8-13,15-16H,6-7,14H2,1-5H3,(H,28,29)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair