BDBM27965 3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-6-yl}-1-[4-(piperazin-1-yl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine::substituted pyrazolopyrimidine, 10
SMILES: COc1ccccc1Cc1nc2ccc(cc2[nH]1)-c1nn([C@H]2CC[C@@H](CC2)N2CCNCC2)c2ncnc(N)c12
InChI Key: InChIKey=MWTCMQXTURNBFI-HZCBDIJESA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Insulin-like growth factor I receptor (Homo sapiens (Human)) | BDBM27965 (3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM27965 (3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EGF-R Tyrosine Kinase Mutant (L858R) (Homo sapiens (Human)) | BDBM27965 (3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair |