BDBM28017 6-{[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino}-N-(2-phenoxyethyl)-2-(3,4,5-trimethoxyphenyl)pyridine-3-carboxamide::trisubstituted pyridine analogue, 18c

SMILES: COc1cc(cc(OC)c1OC)-c1nc(N[C@H](CO)Cc2ccccc2)ccc1C(=O)NCCOc1ccccc1

InChI Key: InChIKey=FCBOUJYKAGWYQM-DEOSSOPVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28017   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM28017 (6-{[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino}-N-(2...) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(N[C@H](CO)Cc2ccccc2)ccc1C(=O)NCCOc1ccccc1 |r| Show InChI InChI=1S/C32H35N3O6/c1-38-27-19-23(20-28(39-2)31(27)40-3)30-26(32(37)33-16-17-41-25-12-8-5-9-13-25)14-15-29(35-30)34-24(21-36)18-22-10-6-4-7-11-22/h4-15,19-20,24,36H,16-18,21H2,1-3H3,(H,33,37)(H,34,35)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Antagonist activity of test compounds was measured in HEK293 cells stably expressing the human recombinant CaR (HEK-CaR) by determining the ability o...				J Med Chem 52: 1204-8 (2009) Article DOI: 10.1021/jm801178c BindingDB Entry DOI: 10.7270/Q2416VCR
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