null

SMILES: C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F

InChI Key: InChIKey=OUBQQWXHNONJNU-NSHDSACASA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 280336   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Bone morphogenetic protein 10 (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Activin receptor type-1B (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Mus musculus (Mouse))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
Activin receptor type-1 (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
Activin receptor type-1B (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1B (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	9.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Homo sapiens (Human))	BDBM280336 (4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...) Show SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F |r| Show InChI InChI=1S/C20H17BrClFN4O2/c1-11(28)8-26-20(29)14-9-24-5-4-17(14)27-19-7-18(25-10-15(19)21)13-6-12(22)2-3-16(13)23/h2-7,9-11,28H,8H2,1H3,(H,26,29)(H,24,25,27)/t11-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair