BDBM281584 US10022461, Compound 31-1

SMILES: OCCC1CCN(CC1)c1ccc(nc1)-n1ccc2ccncc12

InChI Key: InChIKey=YNDYXKQHMFKBHE-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281584   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Microtubule-associated protein tau (Homo sapiens (Human))	BDBM281584 (US10022461, Compound 31-1) Show SMILES OCCC1CCN(CC1)c1ccc(nc1)-n1ccc2ccncc12 Show InChI InChI=1S/C19H22N4O/c24-12-7-15-4-9-22(10-5-15)17-1-2-19(21-13-17)23-11-6-16-3-8-20-14-18(16)23/h1-3,6,8,11,13-15,24H,4-5,7,9-10,12H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.54	-11.5	n/a	n/a	n/a	n/a	n/a	7.4	25
Merck Sharp & Dohme Corp. US Patent					Assay Description For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...				US Patent US10022461 (2018) BindingDB Entry DOI: 10.7270/Q2959KK6
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