BDBM281643 US10022461, Compound 113
SMILES: Nc1cc(F)c2cnc(cc2c1)-n1ccc2ccncc12
InChI Key: InChIKey=AMFYZTDDXLDRTR-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Microtubule-associated protein tau (Homo sapiens (Human)) | BDBM281643 (US10022461, Compound 113) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.784 | -12.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w... | US Patent US10022461 (2018) BindingDB Entry DOI: 10.7270/Q2959KK6 | |||||||||||
More data for this Ligand-Target Pair |