BDBM281728 (+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluo-3-methylbutanoyl]amino}phenyl)-4-methylpentanoic acid (diastereomer 1)::US10023528, Example 1::US10259776, Example 2
SMILES: CC(C)C(CC(O)=O)c1ccc(Cl)c(NC(=O)[C@@H]([C@@H](C)C(F)(F)F)c2ccc(Cl)cc2)c1
InChI Key: InChIKey=IYIIYLRYFLBIJB-KVCBOLPTSA-N
Data: 3 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281728 ((+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 22 | n/a | n/a | 7.5 | 25 |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23... | US Patent US10023528 (2018) BindingDB Entry DOI: 10.7270/Q21N834J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281728 ((+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 89 | n/a | n/a | n/a | n/a |
Institut de Biologie Structurale | Assay Description Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be... | J Med Chem 51: 1115-25 (2008) BindingDB Entry DOI: 10.7270/Q27083RX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human)) | BDBM281728 ((+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 22 | n/a | n/a | n/a | n/a |
Institut de Biologie Structurale | Assay Description Soluble guanylate cyclase (sGC) converts on stimulation GTP into cGMP and pyrophosphate (PPi). PPi is detected with the aid of the assay described be... | J Med Chem 51: 1115-25 (2008) BindingDB Entry DOI: 10.7270/Q27083RX | |||||||||||
More data for this Ligand-Target Pair |