BDBM28184 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[3-(dimethylamino)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 35

SMILES: COc1cc2ncn(-c3cc(OCc4cccc(c4)N(C)C)c(s3)C(N)=O)c2cc1OC

InChI Key: InChIKey=OKLYPNBPHHIICB-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28184   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM28184 (5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[3-(d...) Show SMILES COc1cc2ncn(-c3cc(OCc4cccc(c4)N(C)C)c(s3)C(N)=O)c2cc1OC Show InChI InChI=1S/C23H24N4O4S/c1-26(2)15-7-5-6-14(8-15)12-31-20-11-21(32-22(20)23(24)28)27-13-25-16-9-18(29-3)19(30-4)10-17(16)27/h5-11,13H,12H2,1-4H3,(H2,24,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...				Bioorg Med Chem Lett 19: 1018-21 (2009) Article DOI: 10.1016/j.bmcl.2008.11.041 BindingDB Entry DOI: 10.7270/Q26T0JZX
					More data for this Ligand-Target Pair