BDBM282856 6-(4-(3-chloro-4-fluorophenyl)-1-(2-cyclopropylethyl)- 1H-imidazol-5-yl)imidazo[1,2-b]pyridazine-3- carbonitrile::US10287295, Example 61'::US9884868, Example 61'

SMILES: Fc1ccc(cc1Cl)-c1ncn(CCC2CC2)c1-c1ccc2ncc(C#N)n2n1

InChI Key: InChIKey=ZZJKELSKFYPVHQ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 282856   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282856 (6-(4-(3-chloro-4-fluorophenyl)-1-(2-cyclopropyleth...) Show SMILES Fc1ccc(cc1Cl)-c1ncn(CCC2CC2)c1-c1ccc2ncc(C#N)n2n1 Show InChI InChI=1S/C21H16ClFN6/c22-16-9-14(3-4-17(16)23)20-21(28(12-26-20)8-7-13-1-2-13)18-5-6-19-25-11-15(10-24)29(19)27-18/h3-6,9,11-13H,1-2,7-8H2	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282856 (6-(4-(3-chloro-4-fluorophenyl)-1-(2-cyclopropyleth...) Show SMILES Fc1ccc(cc1Cl)-c1ncn(CCC2CC2)c1-c1ccc2ncc(C#N)n2n1 Show InChI InChI=1S/C21H16ClFN6/c22-16-9-14(3-4-17(16)23)20-21(28(12-26-20)8-7-13-1-2-13)18-5-6-19-25-11-15(10-24)29(19)27-18/h3-6,9,11-13H,1-2,7-8H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-betaR1 T204D (Homo sapiens (Human))	BDBM282856 (6-(4-(3-chloro-4-fluorophenyl)-1-(2-cyclopropyleth...) Show SMILES Fc1ccc(cc1Cl)-c1ncn(CCC2CC2)c1-c1ccc2ncc(C#N)n2n1 Show InChI InChI=1S/C21H16ClFN6/c22-16-9-14(3-4-17(16)23)20-21(28(12-26-20)8-7-13-1-2-13)18-5-6-19-25-11-15(10-24)29(19)27-18/h3-6,9,11-13H,1-2,7-8H2	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282856 (6-(4-(3-chloro-4-fluorophenyl)-1-(2-cyclopropyleth...) Show SMILES Fc1ccc(cc1Cl)-c1ncn(CCC2CC2)c1-c1ccc2ncc(C#N)n2n1 Show InChI InChI=1S/C21H16ClFN6/c22-16-9-14(3-4-17(16)23)20-21(28(12-26-20)8-7-13-1-2-13)18-5-6-19-25-11-15(10-24)29(19)27-18/h3-6,9,11-13H,1-2,7-8H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent									US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair