BDBM282900 6-(4-(3-Chlorophenyl)-2-methyl-1H-imidazol-5- yl)quinoline::US10287295, Example 105::US9884868, Example 105

SMILES: Cc1nc(c([nH]1)-c1ccc2ncccc2c1)-c1cccc(Cl)c1

InChI Key: InChIKey=UFWWTBXPJRUJSU-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 282900   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282900 (6-(4-(3-Chlorophenyl)-2-methyl-1H-imidazol-5- yl)q...) Show SMILES Cc1nc(c([nH]1)-c1ccc2ncccc2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H14ClN3/c1-12-22-18(14-4-2-6-16(20)11-14)19(23-12)15-7-8-17-13(10-15)5-3-9-21-17/h2-11H,1H3,(H,22,23)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282900 (6-(4-(3-Chlorophenyl)-2-methyl-1H-imidazol-5- yl)q...) Show SMILES Cc1nc(c([nH]1)-c1ccc2ncccc2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H14ClN3/c1-12-22-18(14-4-2-6-16(20)11-14)19(23-12)15-7-8-17-13(10-15)5-3-9-21-17/h2-11H,1H3,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.93E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-betaR1 T204D (Homo sapiens (Human))	BDBM282900 (6-(4-(3-Chlorophenyl)-2-methyl-1H-imidazol-5- yl)q...) Show SMILES Cc1nc(c([nH]1)-c1ccc2ncccc2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H14ClN3/c1-12-22-18(14-4-2-6-16(20)11-14)19(23-12)15-7-8-17-13(10-15)5-3-9-21-17/h2-11H,1H3,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2B85BFB
					More data for this Ligand-Target Pair
TGF-beta receptor type II (Homo sapiens (Human))	BDBM282900 (6-(4-(3-Chlorophenyl)-2-methyl-1H-imidazol-5- yl)q...) Show SMILES Cc1nc(c([nH]1)-c1ccc2ncccc2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H14ClN3/c1-12-22-18(14-4-2-6-16(20)11-14)19(23-12)15-7-8-17-13(10-15)5-3-9-21-17/h2-11H,1H3,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.93E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent									US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair