BDBM28324 (1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfonamido}-2-phenylcyclopropane-1-carboxylic acid::sulfonylamino-alkanecarboxylate, 38

SMILES: OC(=O)[C@]1(C[C@H]1c1ccccc1)N(CCN1CCOC1=O)S(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1

InChI Key: InChIKey=CSCGLFLCRANIKK-RPLLCQBOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28324   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ADAMTS-5 (Aggrecanase-2) (Homo sapiens (Human))	BDBM28324 ((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2-oxo-1,...) Show SMILES OC(=O)[C@]1(C[C@H]1c1ccccc1)N(CCN1CCOC1=O)S(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C27H25ClN2O6S/c28-22-10-6-19(7-11-22)20-8-12-23(13-9-20)37(34,35)30(15-14-29-16-17-36-26(29)33)27(25(31)32)18-24(27)21-4-2-1-3-5-21/h1-13,24H,14-18H2,(H,31,32)/t24-,27+/m0/s1	PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	7.5	37
Japan Tobacco Inc.					Assay Description The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...				Bioorg Med Chem Lett 19: 1575-80 (2009) Article DOI: 10.1016/j.bmcl.2009.02.024 BindingDB Entry DOI: 10.7270/Q2PV6HPW
					More data for this Ligand-Target Pair