null

SMILES: Fc1ccc(F)c(Cn2ncc3cc(Nc4ncnc5cc(sc45)C#C[C@@H]4C[C@H](CN4)OC(=O)N4CCOCC4)ccc23)c1

InChI Key: InChIKey=HRADRJGXRLBLGD-ISKFKSNPSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 28503   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM28503 ((3R,5S)-5-{2-[4-({1-[(2,5-difluorophenyl)methyl]-1...) Show SMILES Fc1ccc(F)c(Cn2ncc3cc(Nc4ncnc5cc(sc45)C#C[C@@H]4C[C@H](CN4)OC(=O)N4CCOCC4)ccc23)c1 |r| Show InChI InChI=1S/C31H27F2N7O3S/c32-21-1-5-26(33)20(11-21)17-40-28-6-3-23(12-19(28)15-37-40)38-30-29-27(35-18-36-30)14-25(44-29)4-2-22-13-24(16-34-22)43-31(41)39-7-9-42-10-8-39/h1,3,5-6,11-12,14-15,18,22,24,34H,7-10,13,16-17H2,(H,35,36,38)/t22-,24-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays were performed in 96-well polystyrene round-bottomed plates in reaction buffer containing biotinylated substrate and purified kinase in the pr...				Bioorg Med Chem Lett 19: 1332-6 (2009) Article DOI: 10.1016/j.bmcl.2009.01.080 BindingDB Entry DOI: 10.7270/Q2SN078S
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM28503 ((3R,5S)-5-{2-[4-({1-[(2,5-difluorophenyl)methyl]-1...) Show SMILES Fc1ccc(F)c(Cn2ncc3cc(Nc4ncnc5cc(sc45)C#C[C@@H]4C[C@H](CN4)OC(=O)N4CCOCC4)ccc23)c1 |r| Show InChI InChI=1S/C31H27F2N7O3S/c32-21-1-5-26(33)20(11-21)17-40-28-6-3-23(12-19(28)15-37-40)38-30-29-27(35-18-36-30)14-25(44-29)4-2-22-13-24(16-34-22)43-31(41)39-7-9-42-10-8-39/h1,3,5-6,11-12,14-15,18,22,24,34H,7-10,13,16-17H2,(H,35,36,38)/t22-,24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays were performed in 96-well polystyrene round-bottomed plates in reaction buffer containing biotinylated substrate and purified kinase in the pr...				Bioorg Med Chem Lett 19: 1332-6 (2009) Article DOI: 10.1016/j.bmcl.2009.01.080 BindingDB Entry DOI: 10.7270/Q2SN078S
					More data for this Ligand-Target Pair