BDBM28529 Azepino[4,5-b]indole, 1::ethyl 3-[(4-fluorophenyl)carbonyl]-1H,2H,3H,6H-azepino[4,5-b]indole-5-carboxylate
SMILES: CCOC(=O)C1=CN(CCc2c1[nH]c1ccccc21)C(=O)c1ccc(F)cc1
InChI Key: InChIKey=OBGFIJHGDTXLPB-UHFFFAOYSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Bile acid receptor (Homo sapiens (Human)) | BDBM28529![]() (Azepino[4,5-b]indole, 1 | ethyl 3-[(4-fluorophenyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 600 | n/a | n/a | 7.0 | 22 |
Exelixis Inc. | Assay Description The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter... | J Med Chem 52: 904-7 (2009) Article DOI: 10.1021/jm8014124 BindingDB Entry DOI: 10.7270/Q2J38QVJ | |||||||||||
More data for this Ligand-Target Pair |