BDBM285507 4-{4-Cyano-2-[({(2′R,4S)-7-methoxy-6-[(2-methoxyethyl)carbamoyl]-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl}carbonyl)amino]phenyl}butanoic acid::US10077247, Example 33-2

SMILES: COCCNC(=O)c1cc2c(OCC[C@]22C[C@H]2C(=O)Nc2cc(ccc2CCCC(O)=O)C#N)cc1OC

InChI Key: InChIKey=QTPFRUHAKLYJNL-KMRXNPHXSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 285507   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM285507 (4-{4-Cyano-2-[({(2′R,4S)-7-methoxy-6-[(2-met...) Show SMILES COCCNC(=O)c1cc2c(OCC[C@]22C[C@H]2C(=O)Nc2cc(ccc2CCCC(O)=O)C#N)cc1OC |r| Show InChI InChI=1S/C28H31N3O7/c1-36-11-9-30-26(34)19-13-20-24(14-23(19)37-2)38-10-8-28(20)15-21(28)27(35)31-22-12-17(16-29)6-7-18(22)4-3-5-25(32)33/h6-7,12-14,21H,3-5,8-11,15H2,1-2H3,(H,30,34)(H,31,35)(H,32,33)/t21-,28-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	25
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...				US Patent US10077247 (2018) BindingDB Entry DOI: 10.7270/Q22J6DWN
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