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BDBM285659 US10077273, Compound 68::US10584132, Compound 68::US10934305, Compound 68

SMILES: CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCC(O)=O)C#N

InChI Key:

Data: 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 285659
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285659 (US10077273, Compound 68 \| US10584132, Compound 68 ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
The Trustees of Princeton University US Patent					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic (Homo sapiens (Human))	BDBM285659 (US10077273, Compound 68 \| US10584132, Compound 68 ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10077273 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XHK
The Trustees of Princeton University US Patent					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285659 (US10077273, Compound 68 \| US10584132, Compound 68 ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021)
The Trustees of Princeton University US Patent					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic (Homo sapiens (Human))	BDBM285659 (US10077273, Compound 68 \| US10584132, Compound 68 ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent									US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
The Trustees of Princeton University US Patent					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, cytosolic (Homo sapiens (Human))	BDBM285659 (US10077273, Compound 68 \| US10584132, Compound 68 ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...				US Patent US10934305 (2021)
The Trustees of Princeton University US Patent					More data for this Ligand-Target Pair
Serine hydroxymethyltransferase, mitochondrial (Homo sapiens (Human))	BDBM285659 (US10077273, Compound 68 \| US10584132, Compound 68 ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Princeton University US Patent					Assay Description Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...				US Patent US10584132 (2020) BindingDB Entry DOI: 10.7270/Q2K939XZ
The Trustees of Princeton University US Patent					More data for this Ligand-Target Pair