BDBM285966 US10081617, Example 113::US10081617, Example 114::methyl (4-{2-[4-chloro-3-(5- chloro-2-cyanophenyl)-7- hydroxy-1-oxido-6,7-dihydro- 5H-cyclopenta[b]pyridin-7-yl]- 1H-imidazol-4- yl}phenyl)carbamate

SMILES: COC(=O)Nc1ccc(cc1)-c1c[nH]c(n1)C1(O)CCc2c1[n+]([O-])cc(c2Cl)-c1cc(Cl)ccc1C#N

InChI Key:

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285966   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor XI (Homo sapiens (Human))	BDBM285966 (US10081617, Example 113 | US10081617, Example 114 ...) Show SMILES COC(=O)Nc1ccc(cc1)-c1c[nH]c(n1)C1(O)CCc2c1[n+]([O-])cc(c2Cl)-c1cc(Cl)ccc1C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	813	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...				US Patent US10081617 (2018) BindingDB Entry DOI: 10.7270/Q2CR5WDN
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM285966 (US10081617, Example 113 | US10081617, Example 114 ...) Show SMILES COC(=O)Nc1ccc(cc1)-c1c[nH]c(n1)C1(O)CCc2c1[n+]([O-])cc(c2Cl)-c1cc(Cl)ccc1C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.05	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...				US Patent US10081617 (2018) BindingDB Entry DOI: 10.7270/Q2CR5WDN
					More data for this Ligand-Target Pair