BDBM286030 N-(2-(4-Chlorophenyl)-1-methyl-1H-indol-5-yl-2-(difluoromethyl)-5-((2-methylpropanoylamino)methyl)nicotinamide::US10081629, Example 13

SMILES: CC(C)C(=O)NCc1cnc(C(F)F)c(c1)C(=O)Nc1ccc2n(C)c(cc2c1)-c1ccc(Cl)cc1

InChI Key: InChIKey=YUIOGBYMKCNGAS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 286030   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase (Homo sapiens (Human))	BDBM286030 (N-(2-(4-Chlorophenyl)-1-methyl-1H-indol-5-yl-2-(di...) Show SMILES CC(C)C(=O)NCc1cnc(C(F)F)c(c1)C(=O)Nc1ccc2n(C)c(cc2c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C27H25ClF2N4O2/c1-15(2)26(35)32-14-16-10-21(24(25(29)30)31-13-16)27(36)33-20-8-9-22-18(11-20)12-23(34(22)3)17-4-6-19(28)7-5-17/h4-13,15,25H,14H2,1-3H3,(H,32,35)(H,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.7	n/a	n/a	n/a	n/a	n/a	n/a
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd. US Patent					Assay Description mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...				US Patent US10081629 (2018) BindingDB Entry DOI: 10.7270/Q20K2BMF
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM286030 (N-(2-(4-Chlorophenyl)-1-methyl-1H-indol-5-yl-2-(di...) Show SMILES CC(C)C(=O)NCc1cnc(C(F)F)c(c1)C(=O)Nc1ccc2n(C)c(cc2c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C27H25ClF2N4O2/c1-15(2)26(35)32-14-16-10-21(24(25(29)30)31-13-16)27(36)33-20-8-9-22-18(11-20)12-23(34(22)3)17-4-6-19(28)7-5-17/h4-13,15,25H,14H2,1-3H3,(H,32,35)(H,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.43	n/a	n/a	n/a	n/a	n/a	n/a
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd. US Patent					Assay Description mPGES1 was diluted with assay buffer and added into plate at 49 μL/well supplemented with 1 μL of compound (the final concentration of each...				US Patent US10081629 (2018) BindingDB Entry DOI: 10.7270/Q20K2BMF
					More data for this Ligand-Target Pair