BDBM286085 1-benzyl-N-(1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indol-7-yl)-1H-pyrazole-4-carboxamide::US10081632, Compound 12::US10758530, Compound 12::US9771366, Compound 12

SMILES: O=C(Nc1ccc2cc3C(=O)NCCn3c2c1)c1cnn(Cc2ccccc2)c1

InChI Key: InChIKey=MXJJVWSXWJYCPL-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 286085   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human))	BDBM286085 (1-benzyl-N-(1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a...) Show SMILES O=C(Nc1ccc2cc3C(=O)NCCn3c2c1)c1cnn(Cc2ccccc2)c1 Show InChI InChI=1S/C22H19N5O2/c28-21(17-12-24-26(14-17)13-15-4-2-1-3-5-15)25-18-7-6-16-10-20-22(29)23-8-9-27(20)19(16)11-18/h1-7,10-12,14H,8-9,13H2,(H,23,29)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
PHOENIX MOLECULAR DESIGNS US Patent					Assay Description The assay was initiated by the addition of 33P-ATP and the reaction mixture incubated at 30° C. for 15 minutes. After the incubation period, the assa...				US Patent US10081632 (2018) BindingDB Entry DOI: 10.7270/Q2VT1V45
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha 2 (RSK2) (Homo sapiens (Human))	BDBM286085 (1-benzyl-N-(1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a...) Show SMILES O=C(Nc1ccc2cc3C(=O)NCCn3c2c1)c1cnn(Cc2ccccc2)c1 Show InChI InChI=1S/C22H19N5O2/c28-21(17-12-24-26(14-17)13-15-4-2-1-3-5-15)25-18-7-6-16-10-20-22(29)23-8-9-27(20)19(16)11-18/h1-7,10-12,14H,8-9,13H2,(H,23,29)(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
PHOENIX MOLECULAR DESIGNS US Patent					Assay Description Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin...				US Patent US10758530 (2020)
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha 2 (Homo sapiens (Human))	BDBM286085 (1-benzyl-N-(1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a...) Show SMILES O=C(Nc1ccc2cc3C(=O)NCCn3c2c1)c1cnn(Cc2ccccc2)c1 Show InChI InChI=1S/C22H19N5O2/c28-21(17-12-24-26(14-17)13-15-4-2-1-3-5-15)25-18-7-6-16-10-20-22(29)23-8-9-27(20)19(16)11-18/h1-7,10-12,14H,8-9,13H2,(H,23,29)(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
PHOENIX MOLECULAR DESIGN US Patent					Assay Description Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio...				US Patent US9771366 (2017) BindingDB Entry DOI: 10.7270/Q2862JK5
					More data for this Ligand-Target Pair