BDBM286227 N4-(6,6-dimethyl-5-{[(2S)-2,4,5,5-tetramethylpiperazin-1-yl]carbonyl}-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-N2-ethyl-5-fluoropyrimidine-2,4-diamine::US9518060, Example A1

SMILES: CCNc1ncc(F)c(Nc2n[nH]c3c2CN(C(=O)N2CC(C)(C)N(C)C[C@@H]2C)C3(C)C)n1

InChI Key: InChIKey=DOIUTSAXPOMBSB-ZDUSSCGKSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 286227   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PTK2B protein tyrosine kinase 2 beta (PTK2B) (Homo sapiens (Human))	BDBM286227 (N4-(6,6-dimethyl-5-{[(2S)-2,4,5,5-tetramethylpiper...) Show SMILES CCNc1ncc(F)c(Nc2n[nH]c3c2CN(C(=O)N2CC(C)(C)N(C)C[C@@H]2C)C3(C)C)n1 |r| Show InChI InChI=1S/C22H34FN9O/c1-8-24-19-25-9-15(23)18(27-19)26-17-14-11-32(22(5,6)16(14)28-29-17)20(33)31-12-21(3,4)30(7)10-13(31)2/h9,13H,8,10-12H2,1-7H3,(H3,24,25,26,27,28,29)/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.69	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
PFIZER INC. US Patent					Assay Description Protein Kinase C beta 2 (PKCβII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...				US Patent US9518060 (2016) BindingDB Entry DOI: 10.7270/Q2ZK5JPN
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