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SMILES: CN(C1CN(C1)C(=O)C=C)c1ccc(C(N)=O)c2[nH]c(C)cc12

InChI Key: InChIKey=UHFLGIUCXWTDNE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 287426   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK [393-659]


(Homo sapiens (Human))		BDBM287426
PNG
(US9567339, Example E.9.25)
Show SMILES CN(C1CN(C1)C(=O)C=C)c1ccc(C(N)=O)c2[nH]c(C)cc12
Show InChI InChI=1S/C17H20N4O2/c1-4-15(22)21-8-11(9-21)20(3)14-6-5-12(17(18)23)16-13(14)7-10(2)19-16/h4-7,11,19H,1,8-9H2,2-3H3,(H2,18,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/a6.525



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...

US Patent US9567339 (2017)


BindingDB Entry DOI: 10.7270/Q2P2715T
More data for this
Ligand-Target Pair