BDBM287435 US9567339, Example E.9.34

SMILES: NC(=O)c1ncc(NC2CN(C2)C(=O)C=C)c2cc[nH]c12

InChI Key: InChIKey=NLZLVNATYQDQOK-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 287435   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM287435 (US9567339, Example E.9.34) Show SMILES NC(=O)c1ncc(NC2CN(C2)C(=O)C=C)c2cc[nH]c12 Show InChI InChI=1S/C14H15N5O2/c1-2-11(20)19-6-8(7-19)18-10-5-17-13(14(15)21)12-9(10)3-4-16-12/h2-5,8,16,18H,1,6-7H2,(H2,15,21)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	6.5	25
AbbVie Inc. US Patent					Assay Description The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...				US Patent US9567339 (2017) BindingDB Entry DOI: 10.7270/Q2P2715T
					More data for this Ligand-Target Pair