null

SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)cc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O

InChI Key: InChIKey=AGDQTRSAMIIWTQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287554   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287554 (1-(3-(4-acryloylpiperazin-1-yl)propyl)-7-amino-3-(...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)cc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(3.33,8.09,;2,7.32,;2,5.78,;3.33,5,;3.33,3.46,;4.67,2.69,;6,3.46,;2,2.69,;2,1.15,;.67,3.46,;.67,5,;-.67,5.77,;-.67,2.69,;-2,3.46,;-3.33,2.69,;-4.67,3.46,;-6,2.69,;-6,1.15,;-7.34,.38,;-4.67,.38,;-3.33,1.15,;-2,.38,;-2,-1.16,;-.67,-1.93,;-.67,-3.47,;.67,-4.24,;.67,-5.78,;2,-6.55,;3.33,-5.78,;3.33,-4.24,;2,-3.46,;4.67,-6.55,;4.67,-8.09,;6,-5.78,;7.34,-6.55,;-.67,1.15,;.67,.38,)| Show InChI InChI=1S/C26H29Cl2N5O4/c1-4-22(34)32-10-8-31(9-11-32)6-5-7-33-18-13-21(29)30-15-16(18)12-17(26(33)35)23-24(27)19(36-2)14-20(37-3)25(23)28/h4,12-15H,1,5-11H2,2-3H3,(H2,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB850W
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM287554 (1-(3-(4-acryloylpiperazin-1-yl)propyl)-7-amino-3-(...) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)cc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(3.33,8.09,;2,7.32,;2,5.78,;3.33,5,;3.33,3.46,;4.67,2.69,;6,3.46,;2,2.69,;2,1.15,;.67,3.46,;.67,5,;-.67,5.77,;-.67,2.69,;-2,3.46,;-3.33,2.69,;-4.67,3.46,;-6,2.69,;-6,1.15,;-7.34,.38,;-4.67,.38,;-3.33,1.15,;-2,.38,;-2,-1.16,;-.67,-1.93,;-.67,-3.47,;.67,-4.24,;.67,-5.78,;2,-6.55,;3.33,-5.78,;3.33,-4.24,;2,-3.46,;4.67,-6.55,;4.67,-8.09,;6,-5.78,;7.34,-6.55,;-.67,1.15,;.67,.38,)| Show InChI InChI=1S/C26H29Cl2N5O4/c1-4-22(34)32-10-8-31(9-11-32)6-5-7-33-18-13-21(29)30-15-16(18)12-17(26(33)35)23-24(27)19(36-2)14-20(37-3)25(23)28/h4,12-15H,1,5-11H2,2-3H3,(H2,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	25
Principia Biopharma, Inc. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...				US Patent US9567334 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HKQ
					More data for this Ligand-Target Pair