null

SMILES: O=C(C1CC2(C1)CC(=O)C2)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1

InChI Key: InChIKey=WCSCCAQCZREGKE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287905   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human))	BDBM287905 (6-[(8-Morpholin-4-yl-5,11-dihydro-6H-pyrido[2,3-b]...) Show SMILES O=C(C1CC2(C1)CC(=O)C2)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 Show InChI InChI=1S/C24H26N4O3/c29-19-13-24(14-19)11-17(12-24)23(30)28-15-16-2-1-5-25-22(16)26-20-4-3-18(10-21(20)28)27-6-8-31-9-7-27/h1-5,10,17H,6-9,11-15H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...				US Patent US10508108 (2019) BindingDB Entry DOI: 10.7270/Q2N018X9
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human))	BDBM287905 (6-[(8-Morpholin-4-yl-5,11-dihydro-6H-pyrido[2,3-b]...) Show SMILES O=C(C1CC2(C1)CC(=O)C2)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 Show InChI InChI=1S/C24H26N4O3/c29-19-13-24(14-19)11-17(12-24)23(30)28-15-16-2-1-5-25-22(16)26-20-4-3-18(10-21(20)28)27-6-8-31-9-7-27/h1-5,10,17H,6-9,11-15H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.13E+3	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...				US Patent US10086000 (2018) BindingDB Entry DOI: 10.7270/Q2N58PCG
					More data for this Ligand-Target Pair