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SMILES: Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1ccc(F)cc1

InChI Key: InChIKey=MARDRTGXZRXTIS-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288239   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))		BDBM288239
PNG
(5-(6-(4-Fluorophenyl)-2-(trifluoromethyl)-[1,2,4]t...)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C22H14F4N4O/c1-11-8-14(9-13-10-18(31)28-19(11)13)20-16(12-2-4-15(23)5-3-12)6-7-17-27-21(22(24,25)26)29-30(17)20/h2-9H,10H2,1H3,(H,28,31)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0630n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...

US Patent US10087185 (2018)


BindingDB Entry DOI: 10.7270/Q2QZ2D0H
More data for this
Ligand-Target Pair