BDBM288245 5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-7-yl)-7-chloro-1H-::US10087185, Example 63
SMILES: FC(F)(F)c1cc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
InChI Key: InChIKey=SMARSFKVVXQXQX-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human)) | BDBM288245 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H | |||||||||||
More data for this Ligand-Target Pair |