BDBM288258 2-Cyclopropyl-8-methyl-5-(7-methyl-1H-indazol-5-yl)-::US10087185, Example 76

SMILES: Cc1cc(c(-c2cc(C)c3[nH]ncc3c2)n2nc(nc12)C1CC1)C(F)(F)F

InChI Key: InChIKey=QVNFCTMVFXBOGF-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288258   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288258 (2-Cyclopropyl-8-methyl-5-(7-methyl-1H-indazol-5-yl...) Show SMILES Cc1cc(c(-c2cc(C)c3[nH]ncc3c2)n2nc(nc12)C1CC1)C(F)(F)F Show InChI InChI=1S/C19H16F3N5/c1-9-5-12(7-13-8-23-25-15(9)13)16-14(19(20,21)22)6-10(2)18-24-17(11-3-4-11)26-27(16)18/h5-8,11H,3-4H2,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair