BDBM288275 5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(difluoromethyl)-::US10087185, Example 93

SMILES: CCc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C1CC1

InChI Key: InChIKey=ODIXOGZLQSTQCB-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288275   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288275 (5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(difl...) Show SMILES CCc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C1CC1 Show InChI InChI=1S/C19H16ClF2N5/c1-2-9-6-13(17(21)22)16(27-19(9)24-18(26-27)10-3-4-10)11-5-12-8-23-25-15(12)14(20)7-11/h5-8,10,17H,2-4H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair