BDBM288305 6-(Difluoromethyl)-4-methyl-7-(7-methyl-1H-indazol-5-yl)-2-::US10087185, Example 123

SMILES: Cc1cc(C(F)F)c(-c2cc(C)c3[nH]ncc3c2)n2nc(cc12)C(F)(F)F

InChI Key: InChIKey=IMESJSTYBQGCOM-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288305   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288305 (6-(Difluoromethyl)-4-methyl-7-(7-methyl-1H-indazol...) Show SMILES Cc1cc(C(F)F)c(-c2cc(C)c3[nH]ncc3c2)n2nc(cc12)C(F)(F)F Show InChI InChI=1S/C18H13F5N4/c1-8-4-12(17(19)20)16(27-13(8)6-14(26-27)18(21,22)23)10-3-9(2)15-11(5-10)7-24-25-15/h3-7,17H,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.126	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair