BDBM289097 (−)-1,5-Dimethyl-6-(2-methyl-4-{[3-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)pyrimidine-2,4(1H,3H)-dione (7)::US10093655, Example 7

SMILES: Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)nc(=O)n1C

InChI Key:

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289097   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM289097 ((−)-1,5-Dimethyl-6-(2-methyl-4-{[3-(trifluor...) Show SMILES Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)nc(=O)n1C |(-14.73,-19.08,;-14.73,-20.62,;-16.07,-21.39,;-16.07,-22.93,;-17.4,-23.7,;-17.4,-25.24,;-16.07,-26.01,;-16.07,-27.55,;-17.4,-28.32,;-18.74,-27.55,;-18.74,-26.01,;-20.07,-25.24,;-21.4,-26.01,;-20.07,-23.7,;-20.07,-26.78,;-14.73,-23.7,;-13.4,-22.93,;-13.4,-21.39,;-12.07,-20.62,;-12.07,-19.08,;-13.4,-18.31,;-10.73,-18.31,;-10.73,-16.77,;-9.4,-19.08,;-9.4,-20.62,;-8.07,-21.39,;-10.73,-21.39,;-10.73,-22.93,)| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	8.54	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Inc. US Patent					Assay Description The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...				US Patent US10093655 (2018) BindingDB Entry DOI: 10.7270/Q2SQ92F2
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