BDBM28924 (2S,3S)-N-(5-chlorothiophen-2-yl)-1-hydroxy-3-methylpentane-2-sulfonamido::Begacestat analogue, 8

SMILES: CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)s1

InChI Key: InChIKey=VAIPHPAXOJKZMG-JGVFFNPUSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28924   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-Secretase (Homo sapiens (Human))	BDBM28924 ((2S,3S)-N-(5-chlorothiophen-2-yl)-1-hydroxy-3-meth...) Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)s1 |r| Show InChI InChI=1S/C10H16ClNO3S2/c1-3-7(2)8(6-13)12-17(14,15)10-5-4-9(11)16-10/h4-5,7-8,12-13H,3,6H2,1-2H3/t7-,8+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	297	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ...				J Med Chem 51: 7348-51 (2008) Article DOI: 10.1021/jm801252w BindingDB Entry DOI: 10.7270/Q2BC3WW2
					More data for this Ligand-Target Pair