BDBM28925 (2S)-N-(5-chlorothiophen-2-yl)-3-ethyl-1-hydroxypentane-2-sulfonamido::Begacestat analogue, 9
SMILES: CCC(CC)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)s1
InChI Key: InChIKey=PYZFRRVBPNGCBX-SECBINFHSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Gamma-Secretase (Homo sapiens (Human)) | BDBM28925 ((2S)-N-(5-chlorothiophen-2-yl)-3-ethyl-1-hydroxype...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... | J Med Chem 51: 7348-51 (2008) Article DOI: 10.1021/jm801252w BindingDB Entry DOI: 10.7270/Q2BC3WW2 | |||||||||||
More data for this Ligand-Target Pair |